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G protein-coupled inwardly rectifying potassium (GIRK) channelsgirk can be activated or inhibited by different classes of receptors, suggesting a role for G proteins in determining signaling specificity.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GgirkIRK1, GIRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.

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